The next step in the evolution of skincare is here. It's Structural Skin Tightening—A treatment that delivers all the skin tightening, collagen-boosting power of radiofrequency, with no numbing, needles, or downtime. Just visible results, backed by science and designed for comfort. Unlike conventional RF treatments, the XERF™ treatment delivers energy deeper into the skin—reaching the shallow, middle, and deep layers—where real change begins.
The XERF Structural Skin Tightening treatment is fully personalized, tailored to each patient's unique skin profile and goals.


Learn more about XERF in our in-depth guide

Published XERF research has evaluated both single-session and two-session treatment approaches. In a 2026 prospective multicenter study, all 39 participants who completed the study received two treatments four weeks apart. At Wei Mei, the number of treatments is individualized after your physician assessment.
In the 2026 prospective multicenter study, XERF treatments were spaced four weeks apart. At Wei Mei, if more than one treatment is recommended, your provider will determine the timing based on your individual treatment plan.
At Wei Mei, XERF is typically performed without numbing. This aligns with published human studies, where most participants were treated without topical anesthesia and discomfort was generally described as mild to moderate. Individual comfort varies, and your provider will discuss what to expect before your treatment.
Published human XERF studies report mostly mild and temporary post-treatment reactions. Some participants developed temporary redness and, less commonly, mild swelling; reported reactions resolved within hours to two days. No long-lasting adverse events were reported in these studies.
Published human studies have documented measurable improvement during the first few months after XERF treatment. Single-session studies reported improvement through approximately three months, while a 2026 multicenter two-session study documented clinician-rated improvement at 30 and 90 days after the second treatment.
Published XERF studies currently provide formal follow-up through approximately three months after treatment. Longer-term durability has not yet been established in published human research, so how long individual results last can vary. Your provider can discuss an individualized treatment plan based on your skin and goals.
XERF is designed for adults who want to firm and tighten skin without surgery or downtime. At Wei Mei, XERF is offered for the face, jawline, neck, abdomen, and arms. Every patient is personally assessed by a physician before treatment, with the treatment itself performed by an FNP or licensed esthetician.